Tyrosine phosphorylation in peripheral lymphocytes from patients with systemic lupus erythematosus

A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among all phosphorylated proteins, those called p120, p110, p80 and p55-p60 were more phosphorylated. The level of tyrosine phosphorylation of p120 and p110 proteins discriminated significantly (p = 0.0048, respectively, p = 0.02) between SLE patients and healthy donors. Lymphocytes form SLE patients and healthy donors were then stimulated by cross-linking T cell antigens (CD3, CD4, CD8) to further distinguish the signal transduction between normal and pathologic lymphocytes. No statistical differences in the tyrosine phosphorylation pattern, following CD4 or CD8 cross-linking, were observed between SLE patients and healthy donors lymphocytes. CD3 cross-linking induced an effect on tyrosine phosphorylation different in SLE patients versus healthy donors lymphocytes. Thus, the lymphocytes of SLE patients were refractile in anti-CD3 stimulation in comparison with the healthy donors lymphocytes. Chi-square analysis demonstrated that a significantly larger number of healthy donors responded to anti-CD3 stimulation compared to SLE patients (p = 0.03). The high frequency of tyrosine phosphorylation of p110 and p80 proteins, following CD3 stimulation, in normal versus SLE lymphocytes, suggested that these proteins could be involved in abnormal signal transduction in SLE cells.     

农村水电可持续发展及管理对策

农村水电具有一定的开发优势，但在开发中存在着水能资源管理缺位、部门职责不清、缺乏统一规划和统一调度管理等问题。针对这些问题,从编制流域综合规划、建立和完善水能资源许可制度、加强政府监管力度、实行统一调度、协调水电开发与生态保护的关系等方面提出了管理对策。     

Environmental-aware virtual data center network

Cloud computing services have recently become a ubiquitous service delivery model, covering a wide range of applications from personal file sharing to being an enterprise data warehouse. Building green data center networks providing cloud computing services is an emerging trend in the Information and Communication Technology (ICT) industry, because of Global Warming and the potential GHG emissions resulting from cloud services. As one of the first worldwide initiatives provisioning ICT services entirely based on renewable energy such as solar, wind and hydroelectricity across Canada and around the world, the GreenStar Network (GSN) was developed to dynamically transport user services to be processed in data centers built in proximity to green energy sources, reducing Greenhouse Gas (GHG) emissions of ICT equipments. Regarding the current approach, which focuses mainly in reducing energy consumption at the micro-level through energy efficiency improvements, the overall energy consumption will eventually increase due to the growing demand from new services and users, resulting in an increase in GHG emissions. Based on the cooperation between Mantychore FP7 and the GSN, our approach is, therefore, much broader and more appropriate because it focuses on GHG emission reductions at the macro-level. This article presents some outcomes of our implementation of such a network model, which spans multiple green nodes in Canada, Europe and the USA. The network provides cloud computing services based on dynamic provision of network slices through relocation of virtual data centers.     

茶树尺蛾科典型害虫成虫智能识别技术研究

以设计茶树害虫成虫智能识别应用系统为目的,提出了构建基于图像特征组合智能识别关键技术的三维空间结构（特征组合可分性结构、算法切合度和识别率）研究思想,系统地阐述了三维空间结构的内涵、指标体系、筛选条件、研究模型及实践方法;以尺蛾科典型害虫成虫为实例,认证了研究办法和实现途径的可行性,并对构建智能识别关键技术之三维空间结构知识库的实现路线图进行了展望。     

构建长江开发与保护的和谐关系

阐述了长江流域水资源利用在全国的战略突出地位及合理开发长江水资源的重要性。分析了以往水资源开发中暴露的重大生态环境问题,论述了构建长江水资源开发与生态保护和谐关系的紧迫性。提出了协调长江开发与保护需要探究的主要研究课题：辨识开发中的生态环境制约问题,研究开发对生态环境的叠加累积效应,探讨生态修复补偿及生态调度措施,研究维系健康长江的管理对策。     

丹江口水库水环境问题分析研究

为了掌握南水北调中线工程水源地丹江口水库的水质变化情况,依据多年的水质实测资料,对丹江口库区各地的水污染情况进行了全面分析。分析结果表明：按国家标准,丹江口水库水体水质总体良好,符合国家地面水环境质量标准Ⅱ类水标准;但由于库区经济的快速发展,库区水体水质存在恶化趋势,点源污染依然严重,面源污染日趋严重,部分库湾出现富营养化趋势,且存在一些潜在污染风险源。目前,需要加强丹江口水库库区水质的监测,并采取相应污染控制措施,保障未来南水北调工程的水源质量。     

Analyzing the techniques that improve fault tolerance of aggregation trees in sensor networks

Sensor networks are finding significant applications in large scale distributed systems. One of the basic operations in sensor networks is in-network aggregation. Among the various approaches to in-network aggregation, such as gossip and tree, including the hash-based techniques, the tree-based approaches have better performance and energy-saving characteristics. However, sensor networks are highly prone to failures. Numerous techniques suggested in the literature to counteract the effect of failures have not been carefully analyzed. In this paper, we focus on the performance of these tree-based aggregation techniques in the presence of failures. First, we identify a fault model that captures the important failure traits of the system. Then, we analyze the correctness of simple tree aggregation with our fault model. We then use the same fault model to analyze the techniques that utilize redundant trees to improve the variance. The impact of techniques for maintaining the correctness under faults, such as rebuilding or locally fixing the tree, is then studied under the same fault model. We also do the cost-benefit analysis of using the hash-based schemes which are based on FM sketches. We conclude that these fault tolerance techniques for tree aggregation do not necessarily result in substantial improvement in fault tolerance.     

AGAPIA v0.1: A Programming Language for Interactive Systems and Its Typing System

A model (consisting of rv-systems), a core programming language (for developing rv-programs), several specification and analysis techniques appropriate for modeling, programming and reasoning about interactive computing systems have been recently introduced by Stefanescu using register machines and space-time duality, see [Stefanescu, G. Interactive systems with registers and voices. Fundamenta Informaticae 73 (2006), 285–306. (Early draft, School of Computing, National University of Singapore, July 2004.)]. After that, Dragoi and Stefanescu have developed structured programming techniques for rv-systems and their verification, see, e.g., [Dragoi, C., and G. Stefanescu. Structured programming for interactive rv-systems. Institute of Mathematics of the Romanian Academy, IMAR Preprint 9/2006, Bucharest 2006. Dragoi, C., and G. Stefanescu. Towards a Hoare-like logic for structured rv-programs. Institute of Mathematics of the Romanian Academy, IMAR Preprint 10/2006, Bucharest, 2006. Dragoi, C., and G. Stefanescu. Implementation and verification of ring termination detection protocols using structured rv-programs. Annals of University of Bucharest, Mathematics-Informatics Series, 55 (2006), 129–138. Dragoi, C., and G. Stefanescu. Structured interactive programs with registers and voices and their verification. Draft, Bucharest, January 2007. Dragoi, C., and G. Stefanescu. On compiling structured interactive programs with registers and voices. In: “Proc. SOFSEM 2008,” 259–270. LNCS 4910, Springer, 2008.].In the present paper a kernel programming language AGAPIA v0.1 for interactive systems is introduced. The language contains definitions for complex spatial and temporal data, arithmetic and boolean expressions, modules, and while-programming statements with their temporal, spatial, and spatio-temporal versions. In AGAPIA v0.1 one can write programs for open processes located at various sites and having their temporal windows of adequate reaction to the environment. The main technical part of the paper describes a typing system for AGAPIA v0.1 programs.     

A DEM‐based parallel computing hydrodynamic and transport model

The sudden and accidental water pollution response system (SAWPRS) for Yangtze River in central China required to develop a hydrodynamic and transport model, which is readily available and capable of simulating a large river system within GIS environment. This study facilitates such effort by developing a parallel computing method based on digital elevation model (DEM) using overlapping domain decomposition approach (ODDA) and message passing interface (MPI) protocol. The hydrodynamic and transport model was redesigned using finite volume method for hydrodynamic and transport model dispersion, the SIMPLEC method for solving the flow field, and the pressure weighted interpolating method for the flow field modification. This modelling approach was verified in two experiments using different sets of computer clusters. The model output was evaluated against the measured data collected for the year 1998 for Wanzhou, an upstream river segment of Yangtze River. The relative error was found to be less than 10%. The performance of parallel computation was found excellent as evident from the cost efficiency values greater than 0.81 in both experiments and increased computation speed while increasing the number of computer clusters. Overall, the parallel computing modelling system developed here was found to meet all requirements of SAWPRS. Copyright © 2010 John Wiley & Sons, Ltd.     

Liquid convection effects on the pushing-engulfment transition of insoluble particles by a solidifying interface: Part I. Analytical calculation of the lift forces

During the solidification of a liquid containing insoluble particles, the particles can be instantaneously engulfed, or continuously pushed, or pushed and subsequently engulfed. A critical velocity for the pushing-engulfment transition is observed experimentally. Most models proposed to date ignore the complications arising from the liquid convection ahead of the solid-liquid interface. They simply solve the balance between the attractive drag force exercised by the liquid on the particle and the repulsive interfacial force. This work is an effort to calculate analytically the lift forces (Saffman and Magnus forces) under certain assumptions regarding the nature of fluid flow ahead of the solid/liquid interface. This makes possible the quantitative evaluation of the three experimentally observed regimes occurring during particle-interface interaction: (1) at low convection—no effect on the critical velocity for the particle engulfment transition; (2) at intermediate convection—increased critical velocity; (3) at high convection—no particle-interface interaction. The model was applied to evaluate the gravity level required for microgravity experimental work on particle pushing where the effect of liquid convection during solidification is negligible. This is necessary to validate existing theoretical models that do not take into account fluid flow parallel to the solidification interface.